Nanodiamonds could be the solution for dealing with chemoresistant cancer stem cells, according to a study published in ACS Nano.

A team of researchers, led by Assistant Professor Edward Chow, Junior Principal Investigator at the Cancer Science Institute Singapore (CSI Singapore) at the National University of Singapore, has repurposed existing chemotherapy drugs into effective agents against chemoresistant cancer stem cells with nanotechnology. Chemoresistance, which is the ability of cancer cells to escape chemotherapy treatment, is a primary cause of treatment failure in cancer.

Cancer stem cells, a type of cancer cell which initiates the formation of tumours, are commonly found to be more resistant to chemotherapy than the rest of the bulk tumour, which can lead to cancer recurrence following chemotherapy treatment. As such, there is intense interest in developing new drugs or treatment strategies that overcome chemoresistance, particularly in cancer stem cells. In this study, widely-used chemotherapy drug Epirubicin was attached to nanodiamonds, carbon structures with a diameter of about five nanometres, to develop a nanodiamond-Epirubicin drug delivery complex (EPND).

The researchers found that while both standard Epirubicin as well as EPND were capable of killing normal cancer cells, only EPND was capable of killing chemoresistant cancer stem cells and preventing secondary tumor formation in xenograft models of liver cancer. Compared to other approaches such as combinatorial therapy of chemotherapy drugs with inhibitors of chemoresistance pathways, delivery of existing chemotherapy drugs with nanodiamonds provides a broader range of protection in a package that is both safer and more effective.

The study demonstrated that delivery of Epirubicin by nanodiamonds resulted in a normally lethal dosage of Epirubicin becoming a safe and effective dosage. As such, delivery of chemotherapy drugs by nanodiamonds not only enables enhanced killing of chemoresistant cancer stem cells, but may be a useful alternative for patients who cannot tolerate the toxic side effects of standard chemotherapy drugs.

Furthermore, the versatility of the nanodiamond-based drug delivery platform opens up the possibility of future applications of nanodiamonds such as the addition of other similar drugs as well as active targeting components such as antibodies or peptides against tumour cell surface proteins for targeted drug release.

In addition, the application of a nanodiamond-drug delivery system is not limited to liver cancer. It offers a promising approach to treating a broad range of difficult cancers, particularly those driven by chemoresistant cancer stem cells. In collaboration with Professor Dean Ho at the University of California Los Angeles and Professor Li Jianzhong at Peking University, Chow's group is working towards completing preclinical work on anthracycline delivery by nanodiamonds and hope to begin clinical trials in the near future.